Synthesis and antimicrobial activity evaluation of novel nitrofuranthiazoles

INTRODUCTION The incidence of microbial infections have been increasing day by day in worldwide. Many antibacterial agents are in use against a wide range of infectious diseases1,2. However, the resistance to existing drugs is still a serious problem threat to global public health. This situation leads medicinal chemists to investigate newly synthesized more potent antimicrobial drugs3. Among many antibacterial agents, nitrofuran containing drugs (Figure 1. furazolidone, nitrofurantoin nitrofurazone and furaltadone) have been widely used for protection against microbial and protozoal infections especially associated with food contaminations4. The nitrofurans are characterized by a 5-nitro-2-furanyl group. First synthesized drug nitrofurazone, 5-nitro-2furaldehyde semicarbazone, is still being used molecule due to its antitrypanosomal activity as well as antibacABSTRACT